Search results for "general [Ray burst]"

Inflammatory cytokines shape a changing DNA methylome in monocytes mirroring disease activity in rheumatoid arthritis

2019

Objective: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that mainly targets joints. Monocytes and macrophages are critical in RA pathogenesis and contribute to inflammatory lesions. These extremely plastic cells respond to extracellular signals which cause epigenomic changes that define their pathogenic phenotype. Here, we interrogated how DNA methylation alterations in RA monocytes are determined by extracellular signals. Methods: High-throughput DNA methylation analyses of patients with RA and controls and in vitro cytokine stimulation were used to investigate the underlying mechanisms behind DNA methylation alterations in RA as well as their relationship with clinic…

Etanercept maintains the clinical benefit achieved by infliximab in patients with rheumatoid arthritis who discontinued infliximab because of side ef…

2007

Objective: To evaluate the efficacy of switching to etanercept treatment in patients with rheumatoid arthritis who already responded to infliximab, but presented side effects. Methods: Charts of 553 patients with rheumatoid arthritis were retrospectively reviewed to select patients who responded to the treatment with infliximab and switched to etanercept because of occurrence of adverse effects. Clinical data were gathered during 24 weeks of etanercept treatment and for the same period of infliximab treatment before infliximab was stopped. Disease Activity Score computed on 44 joints (DAS-44), erythrocyte sedimentation rate (ESR) 1st hour, Visual Analogue Scale (VAS) of pain, Health Assessm…

FRI0030 Anti-TNF-α Antibody Targeted To Inflamed Synovial Tissue for The Treatment of Rheumatoid Arthritis

2016

Background TNF-α neutralizing molecules represent one of the most efficient therapeutic approaches to control inflammation in rheumatoid arthritis (RA). The widespread distribution in the body induces the inhibition of TNF-α in all the tissues, requesting the use of high dose of this expensive drug. Another problem that has not yet been solved in the management of RA patients is how to reduce and possibly avoid the side effects, particularly the increased risk of common and opportunistic infections, which may be associated with long-term administration of these therapeutic drugs. Objectives The aim of the present investigation was to show that a recombinant protein obtained by fusing a syno…

Prevención de riesgo psicosocial en adolescentes: el rol de los Centros de Día de Menores en España

2020

espanolEl articulo analiza la funcion de los Centros de Dia de Menores (CDM) como recursos especializados en la intervencion socioeducativa con adolescentes en riesgo. Se trata de una investigacion cualitativa, en la que se han integrado diferentes tecnicas con el fin de triangular evidencias objetivas. En el plano metodologico participo una muestra de 30 profesionales, implementando diferentes tecnicas: entrevistas y grupos de discusion. Los datos obtenidos se codificaron y categorizaron. Los resultados destacan la especificidad de los CDM como recurso de proximidad en el proceso de socializacion y de acompanamiento progresivo, individualizado y flexible de adolescentes en riesgo. Las conc…

Development of high-performance thin layer chromatography method for identification of phenolic compounds and quantification of rosmarinic acid conte…

2020

ABSTRACT Aim: Representatives of Nepetoideae Burnett subfamily are promising species of the Lamiaceae Martinov family because of accumulating such valuable groups of secondary metabolites as terpenoids and polyphenols. A high-performance thin layer chromatography (HPTLC) fingerprint method for the qualitative determination of phenolic compounds and for the quantification of rosmarinic acid (RA) content in methanol extracts of five species of this subfamily was developed for the first time. Materials and Methods: Dried aerial parts of Dracocephalum moldavica L., Ocimum americanum L., Lophanthus anisatus (Nutt.) Benth., Monarda fistulosa L., and Satureja hortensis L. collected in flowering pe…

Scientific productivity and collaboration in viticulture and enology in Latin American countries

2013

[EN] The aim of this study was to analyze the scientific activity of Latin American researchers in viticulture and oenology through bibliometric analyses of articles included in the Science Citation Index Expanded database for the period of 2006 to 2010. A total of 917 research articles were published in 364 domestic and international journals. We highlight the important growth in the number of research papers published during the period, especially in Brazil, Argentina and Chile, as well as an increasing number of international collaborations, mainly with non-American grape- and-wine producing countries. A social network analysis of collaborations between institutions and countries was als…

Enhancing the user authentication process with colour memory cues

2022

The authentication process is the first line of defence against potential impostors, and therefore is an important concern when protecting personal and organisational data. Although there are many options to authenticate digital users, passwords remain the most common authentication mechanism. However, with password numbers increasing, many users struggle with remembering multiple passwords, which affects their security behaviour. Previous researchers and practitioners have attempted to suggest ways to improve password memorability and security simultaneously. We introduce novel approach that utilises colour as a memory cue to increase password memorability and security. A longitudinal stud…

Emotional Profile and Intellectual Functioning

2015

Insufficient literature has been produced addressing children with borderline intellectual functioning (BIF) and gifted intellectual functioning (GIF). The goal of this work is to compare levels of self-esteem, depression, anxiety at school, and insecurity among children with BIF and GIF, and a control group of average intellectual functioning (AIF). There were participants of 104 children (fourth grade of primary school). Analyses revealed that children with BIF showed a lower level of self-esteem and higher levels of depression and school anxiety. Moreover, our findings highlight the co-occurrence of school anxiety, depressed mood, and insecurity among the BIF and AIF groups. One of the …

Journalistinen komiikka : teoreettisia ja käytännöllisiä avauksia

2012

Understanding the sense of community and continuance intention in virtual communities: The role of commitment and type of community

2019

Virtual communities (VCs) have become essential in current organizations and society, and so their sustainability is a topic of interest for researchers and practitioners. We focus on the sense of virtual community (SoVC) and commitment as relevant antecedents in achieving the success and maintenance of different types of VCs (communities of interest, virtual learning communities, and virtual communities of practice). Specifically, this study examines a moderated mediation model in which the type of virtual community moderates the indirect effect of a SoVC on the intention to continue through the perceived commitment of the users of the VC. The sample consists of 299 members of Virtual comm…